But since the Office suite is by default this useless tool, we have Office Timeline Plus 4 for you that can be used to add time tables to PowerPoint slides.
Gantt Chart Gantt chart is one of the most basic and most used charts and charts in project control. In other words, using Gantt charts can define defined projects and track the progress of each of them.
Office Timeline Plus / Pro Edition 4.00.05.00 Description The Gantt Chart is a type of bar chart that illustrates the timing of project execution in an illustrative and comprehensible way.
It does not store any personal data.Office Timeline Plus / Pro Edition 4.00.05.00 is the name of the software that allows users and project managers to take advantage of the timelines in their slides. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Office of the Director, National Institutes of Health, Cold Spring Harbor Laboratory, and Northwell Health Affiliationįisher, M.L., et al., “BRD4 regulates transcription factor ∆Np63α to drive a cancer stem cell phenotype in squamous cell carcinomas”, Cancer Research, October 25, 2021. Written by: Luis Sandoval, Content Developer/Communicator | | 51 This is why we think identifying pathways that include druggable targets is so important.” The discovery of four new therapeutic targets for this disease offers new hope for treating this deadly cancer. Matt Fisher, a postdoctoral fellow in Mills’ lab who led this study, says, “Squamous cell cancer is not an easy cancer to treat right now, and there’s not a lot of therapeutic options. Mice with these cancerous squamous cells treated with these drugs developed smaller tumors.
When the Mills group added these drugs to patient-derived cancer stem cells growing in a Petri dish, the cells became less aggressive, less mobile, and slower growing. Some of these proteins were already known to be involved in promoting other kinds of cancer, so there were already drugs in clinical trials to deactivate them.
Mills’ team identified a cascade of four proteins that act like a series of dominos to activate ∆Np63α. “I think of the cancer stem cells as kind of like a bad seed in your garden that will grow a weed if not surgically removed or somehow controlled.” The tumors can be painful, disfiguring, and difficult to remove. These cancer stem cells invade other tissues and even wrap around the nerves of the face.
When that happens in squamous cells, which form the covering of the skin and many other organs, stem cells grow out of control and form tumors. When one variant of the protein, ∆Np63α, is overactive, stem cell production never turns off. P63 regulates stem cells, which are immature cells that have the potential to grow into different kinds of mature cells. Now they have found a way to stop the dominos from falling, not by turning off ∆Np63α itself, but by turning off other proteins that work together to activate it. Mills and her colleagues have been trying to devise ways to turn it off, but to no avail. More recently, she found that a specific version of p63 (∆Np63α) causes cancer when it is overactive. Twenty-two years ago, Cold Spring Harbor Laboratory (CSHL) Professor Alea Mills discovered the protein p63. Similarly, a lot of pieces have to line up and be pushed at the same time in a cell to result in cancer. In a line of dominos, if you take out a single piece, the last one will never fall. Cold Spring Harbor Laboratory Professor Alea Mills and her research group have discovered a way to deactivate the protein by cutting off a line of other proteins that activate it. When these cells overproduce a cancer-causing protein, they become an aggressive type of cancer with few treatment options. Squamous cells make up the outer layer of the skin and the lining of several other organs.